Figure 1. Mutational signatures in the basal breast tumor.

a, Fraction of mutations in each of the transition and transversion categories in the metastasis of a lobular breast tumor⁹, the metastasis of the basal breast tumor under study, and the 11 breast tumors reported by Wood et al.²⁹ from which 1,104 coding mutations identified in the discovery set were used in the analysis. b, Fraction of mutations in each of the transition and transversion categories in 43 tier1 mutations and 3,204 tier 1-4 mutations in the metastasis under study. c, Fraction of guanine mutations at CpGs in primary tumor, metastasis, xenograft, and NCI-H209 as reported by Pleasance et al.⁷.