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. 2010 May 18;8(5):e1000372. doi: 10.1371/journal.pbio.1000372

Figure 7. Feeding eat-2 worms with Comamonas sp. rescues Dietary Restriction phenotypes.

Figure 7

(A) When fed standard food of E. coli, eat-2(ad465) mutants exhibit a small body size compared to wild type. eat-2(ad465) mutant body size is rescued by feeding animals small bacteria (Comamonas). (B) Quantitation of body size represented in (A). (C) The extended lifespan of eat-2(ad465) mutants is suppressed by feeding with Comamonas. (D) Feeding with Comamonas rescues eat-2(ad465) animals' 16 h memory defect but does not significantly affect wild type's memory. (E) Treatment of eat-2(ad465) worms with pha-4 RNAi abolishes LTAM defect. (B): n = 3 Day 1 adult worms; photos are at same magnification; (C): n>70, WT/E. coli versus eat-2/E. coli: p<0.001; versus eat-2/Comamonas: p = 0.43; versus WT/Comamonas: p = 0.11; (D–E): Numbers under bars represent hours after 7× spaced training; (D): n = 6 trials; (E) n = 3 trials; ± SEM; * p<0.05, ** p<0.01, *** p<0.001.