Figure 1. Longitudinal changes in organ function from onset of symptoms (Day 1).

Biochemical and haematological indices were captured every two days throughout disease course for Patient 1 (column A), Patient 2 (column B) and Patient 3 (column C). Relevant clinical and therapeutic interventions are shown on the urea and creatinine serial graph for each patient. Normal levels are Urea – 2.5–7.5 mmol/l; Creatinine - 40–139 umol/l; Hb - 12.0–17.5 g/dl; lymphocytes – 1.5–3.5×10^∧9/l; monocytes 0.2–0.8×10^∧9/l; neutrophils 2.5–7.5×10^∧9/l; ALT- 0–50U/l; albumin - 32–45 g/l; CRP - 0–10 mg/l.