Table 6. Subsets of expression traits showing robust independent association with the different risk factors in the validation sample.

Risk factor	Median (range) of the global P-values across replicates*	List of gene expressions associated with risk factor after adjustment on covariates$
Gender#	All P<10−100	CCDC106, MMEL1, ANKRD57, CXCR7, FCGR2B, SOX15, FCGBP, LPXN, CD24, HOXA9, PTK6, DDX43, RAB11FIP1, PTK2, CLEC4G, ADARB1, PROK2, MYBPH, PER3, TPPP3, MPO, FAM24B, EMR3, ENOSF1, TPM2, PTTG1IP, CELSR3, CD1A, FOLR2, BOLA3, OPLAH
Age	1.1×10−50(2.9×10−70–3.6×10−37)	PARP3, PDGFRB, NEFH, P2RY2, SPINK2, GPER, NFKBIZ, ZSCAN18, IGLL1, BLK, ITM2C, C1RL
BMI	1.5×10−37(2.6×10−50–2.7×10−26)	CX3CR1, MAP3K6, FCGBP, CD209, LYPD2, VSIG4, RPGRIP1, PACAP, LGALS3BP, ELA2, CD36, ABCA1
HDL-chol	5.5×10−10(2.2×10−15–2.7×10−3)	PRDM1, SCD, DPEP2,TMEM43
LDL-chol	2.3×10−3(3.8×10−7–0.5)	BYSL, ABCA1
Triglycerides	4.2×10−6(2.1×10−11–0.08)	MYLIP, PHGDH, ABCA1, ELA2, ABCG1, SASH1
SBP	5.0×10−20(4.6×10−27–2.6×10−12)	CRIP1, GFOD1, DHRS9, NR4A2, TSC22D3, ARID5B, PAPSS2, HVCN1
DBP	1.8×10−10(3.6×10−16–1.2×10−4)	GFOD1, CRIP1, TPPP3, NR4A2,EMP1
CRP	6.1×10−51(7.3×10−67–2.0×10−30)	FAM20A, CETP, FCGBP, COL9A2, C1RL, ADM, CREB5, APBB1IP, CX3CR1, C1QB, MS4A4A, FCER1A, ALDH1A1, FLVCR2
Smoking	9.7×10−108(1.9×10−128–3.7×10−84)	SASH1, P2RY6, PTGDS, PID1, CYP4F22, MMP25, WWC3, FUCA1, PDE4B, STAB1, GFRA2, CLEC10A, CAMK1D, DHRS9, CNTNAP2, IQCK, ITGB7, SMAD6,

*The global P-value is the P-value obtained by comparing the model with all significant expression traits and covariates to the model with covariates only.

Expressions that are underlined are associated negatively to the risk factor (or to male gender), others are associated positively (or to female gender).

^$Covariates: age and gender for BMI, CRP and smoking; age, gender and BMI for lipids and BP.

^#Gender-associated traits were selected from autosomal genes only.