Table 7. Smoking-related expression traits: association of expression with cis-acting eSNP, smoking and extent of atherosclerosis.

Smoking-related gene expressions	Association of the best cis eSNP with expression		Association of the best cis eSNP with the extent of atherosclerosis		Association of expression with smoking		Association of expression with the extent of atherosclerosis
	SNP number	P-value	t- value	P-value	t- value	P-value	t- value	P-value
CAMK1D	rs4478891	1.1×10−26	0.7	0.51	−7.4	2.3×10−13	−3.1	0.002
CLEC10A	rs367953	3.6×10−12	0.5	0.65	13.0	5.4×10−37	−0.4	0.68
CNTNAP2	rs1110144	8.6×10−12	−1.1	0.28	6.5	7.3×10−11	1.7	0.082
CYP4F22	rs11253478	1.5×10−6	0.0	1.00	−17.5	1.8×10−62	−2.2	0.027
DHRS9	rs1386426	4.3×10−7	2.5	0.012	−6.3	3.5×10−10	0.2	0.82
FUCA1	rs9424398	6.8×10−42	1.0	0.34	13.7	1.4×10−40	2.1	0.035
GFRA2	rs1479056	1.6×10−108	0.5	0.62	13.3	3.1×10−38	0.8	0.44
IQCK	rs1879894	1.1×10−7	0.6	0.52	−7.6	2.7×10−14	−1.7	0.089
ITGB7	rs17080239	1.0×10−6	0.4	0.68	6.3	3.9×10−10	0.3	0.73
MMP25	rs7188573	4.7×10−18	0.0	1.00	15.6	5.4×10−51	3.6	3.51×10−4
P2RY6	rs3781305	9.0×10−7	−1.0	0.34	16.0	1.5×10−53	0.5	0.58
PDE4B	rs4352802	4.5×10−7	−1.2	0.24	−7.7	1.2×10−14	−1.8	0.077
PID1	rs4972894	1.1×10−25	−0.1	0.95	10.5	6.2×10−25	1.4	0.16
PTGDS	rs10870158	6.0×10−9	0.7	0.49	−14.0	3.5×10−42	−5.2	1.77×10−7
SASH1	rs17712470	5.6×10−14	0.5	0.63	20.5	5.1×10−83	4.4	1.38×10−5
SMAD6	rs17264185	2.7×10−15	−1.5	0.13	6.8	9.6×10−12	1.6	0.11
STAB1	rs9867823	2.8×10−28	0.4	0.68	12.3	2.9×10−33	0.7	0.50
WWC3	rs1013478	8.0×10−6	−1.1	0.26	10.6	1.8×10−25	3.4	6.32×10−4

Atherosclerosis was assessed by the number of carotid plaques.

Associations of expressions with smoking and number of carotid plaques were adjusted on gender and age. Cis eSNPs significant at a study-wise level (P<5.78×10⁻¹²) and associations with carotid plaques significant after correction for multiple testing (n = 18 tests) are shown in bold characters.