|
Calcineurin regulation
|
|
|
|
| regulator of calcineurin 1 (RCAN1), transcript variant 3 |
NM_203418.1 |
5.6 |
Calcinuerin regulation |
| regulator of calcineurin 1 (RCAN1), transcript variant 2 |
NM_203417.1 |
3.9 |
Calcinuerin regulation |
|
NFAT
|
|
|
|
| nuclear factor of activated T-cells, (NFATC1), transcript variant 1 |
NM_172390.1 |
1.3 |
calcineurin transcription/regulation |
| glycogen synthase kinase 3 beta (GSK3B) |
NM_002093.2 |
1.3 |
calcineurin transcription/regulation |
|
MAPK regulation
|
|
|
|
|
Activation
|
|
|
|
| mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), transcript variant 2 |
NM_032960.2 |
1.2 |
MAPKKK cascade |
| adrenergic, beta-2-, receptor, surface (ADRB2) |
NM_000024.3 |
2.5 |
activation of MAPK activity |
| mitogen-activated protein kinase 6 (MAPK6) |
NM_002748.2 |
1.3 |
MAP kinase activity |
| mitogen-activated protein kinase kinase kinase 6 (MAP3K6) |
NM_004672.3 |
1.4 |
protein serine/threonine kinase activity |
| mitogen-activated protein kinase kinase kinase 8 (MAP3K8) |
NM_005204.2 |
11.1 |
protein serine/threonine kinase activity |
|
Inactivation
|
|
|
|
| protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform (PPP2CA) |
NM_002715.2 |
1.5 |
inactivation of MAPK activity |
| dual specificity phosphatase 16 (DUSP16) |
NM_030640.1 |
1.8 |
inactivation of MAPK activity |
| dual specificity phosphatase 8 (DUSP8) |
NM_004420.1 |
1.4 |
inactivation of MAPK activity |
|
RHOA
|
|
|
|
| striated muscle activator of Rho-dependant signaling (STARS) |
NM_139166.2 |
10.1 |
positive regulation of Rho protein signal transduction |
| Rho family GTPase 3 (RND3) |
NM_005168.3 |
5.4 |
small GTPase mediated signal transduction |
| Rho guanine nucleotide exchange factor (GEF) 7 (ARHGEF7), transcript variant 2 |
NM_145735.1 |
1.3 |
RHOA positive regulation |
| Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12) |
NM_015313.1 |
1.2 |
RHOA positive regulation |
| Rho GTPase activating protein 24 (ARHGAP24) |
NM_031305.1 |
0.8 |
RHOA negative regulation |
|
Actin cytoskeleton and transcription factor activity
|
|
|
|
| actinin, alpha 1 (ACTN1) |
NM_001102.2 |
1.4 |
actin cytoskeleton |
| diaphanous homolog 1 (Drosophila) (DIAPH1) |
NM_005219.2 |
1.9 |
actin cytoskeleton organization and biogenesis |
| coronin, actin binding protein, 1C (CORO1C) |
NM_014325.2 |
1.5 |
actin binding/cytoskeleton |
| filamin B, beta (actin binding protein 278) (FLNB) |
NM_001457.1 |
1.5 |
actin binding/cytoskeleton |
| actin, alpha 2, smooth muscle, aorta (ACTA2) |
NM_001613.1 |
1.7 |
actin filament |
| jun D proto-oncogene (JUND) |
NM_005354.2 |
1.9 |
activated transcription factor component |
| v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) |
NM_005252.2 |
14.8 |
activated transcription factor component |
| FBJ murine osteosarcoma viral oncogene homolog B (FOSB) |
NM_006732.1 |
3.7 |
activated transcription factor component |
| v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) (MAFF), transcript variant 1 |
NM_012323.2 |
2.6 |
regulation of transcription |
|
Other regulators of muscle growth and remodeling
|
|
|
|
| activating transcription factor 3 (ATF3), transcript variant 3 |
NM_001030287.1 |
28.4 |
transcription factor activity |
| Xin actin-binding repeat containing 1 (XIRP1) |
NM_194293.2 |
13.6 |
actin cytoskeleton organization |
| v-myc myelocytomatosis viral oncogene homolog (avian) (MYC) |
NM_002467.3 |
11.0 |
transcription factor activity |
| heparin-binding EGF-like growth factor (HBEGF) |
NM_001945.1 |
7.0 |
growth factor activity |
| DnaJ (Hsp40) homolog, subfamily B, member 4 (DNAJB4) |
NM_007034.3 |
6.1 |
heat shock protein binding |
