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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Exp Hematol. 2010 Mar 18;38(6):489–503.e1. doi: 10.1016/j.exphem.2010.03.006

Figure 9. A model describing the regulatory regions driving Gata1 expression during the maturation of DCs.

Figure 9

A model is proposed to characterize a dynamic pattern of chromatin configuration in DCs that sequentially recruits the HS1 and HS2 enhancer to control Gata1 expression. In CD11clow cells, Gata1 expression is driven by HS2. In blood cDC precursors, Gata1 expression is controlled by HS2 and HS1 in combination. In mature cDCs from spleen, Gata1 expression is under the control of HS1.