Table 1.

Disposition kinetic parameters of cefpirome in buffalo calves following a single intravenous administration

Cp^o = plasma drug concentration at zero time; t_1/2α and t_1/2β = half-lives of distribution and elimination phases, respectively; K₁₂ and K₂₁ = rate constants defined in the two compartment model; AUC = area under the plasma concentration-time-curve; AUMC = area under the first moment of the plasma concentration-time-curve; Vd_area, Vd_B, and Vd_ss = volume of distribution from AUC, elimination phase, and steady state plasma level, respectively; Cl_B = total body clearance of the drug; K_el = elimination rate constant from the central compartment; MRT = mean residence time of drug in body; T/P = ratio of the drug present in the peripheral to central compartment; tC_ther = duration of therapeutic concentration of drug.