Table 3.

Postoperative recurrence rates and hazard ratios in ARC-subCLSTs among sub-stages

	Crude recurrence rate % [No.]	Hazard ratio [95% CI]
Stage I	P = 0.002	P < 0.001
CLST A1 [36]	2.8 [1]	1.00 [ref.]
A2 [42]	4.8 [2]	1.84 [0.17- 20.26]
B [23]	17.4 [4]	8.07 [0.90- 72.41]
C1 [41]	9.8 [4]	3.90 [0.44- 34.92]
C2 [25]	28.0 [7]	13.51 [1.66-109.98]
D [20]	35.0 [7]	16.49 [2.03-134.14]
Stage IA	P = 0.003	P < 0.001
CLST A1 [32]	3.1 [1]	1.00 [ref.]
A2 [33]	3.0 [1]	1.14 [0.07- 18.30]
B [12]	0.0 [0]	N.A.
C1 [29]	0.0 [0]	N.A.
C2 [16]	12.5 [2]	5.14 [0.47- 56.86]
D [8]	37.5 [3]	18.44 [1.88-181.10]
Stage IB	P = 0.310	P = 0.220
CLST A1 [4]	0.0 [0]	1.00 [ref.]
A2 [9]	11.1 [1]	N.A.
B [11]	36.4 [4]	N.A.
C1 [12]	33.3 [4]	N.A.
C2 [9]	55.6 [5]	N.A.
D [12]	33.3 [4]	N.A.

ARC-subCLSTs, sub-clusters based on architectural elements; No., number of cases; CLST, cluster; P, P value for crude reccyrrence rate and harad ratio are calculated by Fisher's exact test and and Log-rank test, respectively; CI, confidence interval; ref., reference; N.A., not available;

*C3 (squamous cell carcinomas), excluded from anaysis.