Subtractive and divisive scaling of f–I curves with inhibitory synchrony in the computer model. (A) Multiplicative gain modulation with inhibitory synchrony. aIV = 10, from top to bottom σIV=1, 2, 3, 4 and 5 ms. Inset: all curves could be collapsed by a shift in the current and a rescaling of the firing rate axis. (B) Shift in neural sensitivity with inhibitory synchrony, aIV = 50, from left to right, σIV = 1, 3, and 5 ms. The solid lines are fits to a sigmoid function, filled circles are the simulation results. (C, D) Fitting parameters as a function of σIV. (C) The shift ΔI (circles) and firing rate gain λf (squares) necessary to make the curves in (A) collapse on the σIV = 1 reference curve. (D) The midpoint ΔI (circles) and slope λI (squares) of the best-fitting sigmoid. The asterisk labels f–I curves that were not well fitted by a sigmoid.