Table.

Clinical-pathological reports of longitudinally followed subjects with MCI

	Criteria used for MCI diagnosis	Number of MCI subjects	Source of Subjects	Pathology	Braak score
Price & Morris, 1999 [12]	CDR 0.5	15	Washington University ADRC Community-based population	Increased NFT, DP and NP neocortex	N/A
Morris et al. 2001 [17]	CDR 0.5	24	Washington University ADRC Community-based population	21 out of 24 had AD	N/A
Mitchell et al. 2002 [13]	Other	9	Rush University ADC Catholic clergy	NFT in medial temporal lobe but not neuropil threads	N/A
Riley et al. 2002 [14]	Other	17	University of Kentucky Nun Study	NFT prominent	N/A
Bennett et al. 2005 [16]	Other	37	Rush University ADC Catholic clergy	AD pathology and cerebral infarction	mean 3.6
Markesbery et al. 2006 [15]	Petersen et al. CDR 0.5	10	University of Kentucky ADC Community-based population	Predominant NFT in medial temporal lobe structures; modest neocortical NP	mean 3.3
Markesbery unpublished data	Petersen et al CDR 0.5	6	University of Kentucky ADC Community-based population	Predominant NFT in medial temporal lobe structures; modest neocortical NP	mean 3.5
Petersen et al. 2006 [18]	Petersen et al	15	Mayo Clinic ADRC Community-based population	Predominant NFT in medial temporal lobe structures; other heterogeneous pathology	mean 2.9
Jicha et al. 2006 [11]	Petersen et al	34	Mayo Clinic ADRC Community-based population	24 out of 34 had AD	mean 4.1

[reference number]

Abbreviations: AD, Alzheimer’s disease; ADC, Alzheimer’s Disease Center; ADRC, Alzheimer’s Disease Research Center; DP, diffuse plaques; CDR. Clinical Dementia Rating Scale; MCI, mild cognitive impairment; NFT, neurofibrillary tangles; NP, neuritic plaques