Table 3.
Ten highest TIF genes in the small cell lung cancer dataset
| Gene | TIF | t-score (P-value) | KEGG annotation | GO annotation (evidence codea) |
|---|---|---|---|---|
| SPCS1 | 1.33 | 3.87 (0.0001) | Lysine degradation Biotin metabolism |
Function: Molecular_function (ND) Process: Proteolysis (TAS) |
| BTD | 1.33 | 5.60 (2e-8) | Biotin metabolism |
Function: Biotin carboxylase activity (TAS) Process: Central nervous system development (TAS) Epidermis development (TAS) |
| SKP2 | 1.33 | 10.60 (3e-26) | Cell cycle Ubiquitin mediated proteolysis Pathways in cancer Small cell lung cancer |
Function: Protein binding (IPI) Process: G1/S transition of mitotic cell cycle (TAS) Cell proliferation (TAS) |
| CKS1B | 1.33 | 5.31 (1e-7) | Pathways in cancer Small cell lung cancer |
Process: Cell adhesion (NAS) |
| NFKB1 | 1.29 | 5.69 (1e-8) | MAPK signaling pathway Apoptosis Toll-like receptor signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Adipocytokine signaling pathway Epithelial cell signaling in Helicobacter pylori infection Pathways in cancer Pancreatic cancer Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer |
Function: Promoter binding (IDA) Protein binding (IPI) Transcription factor activity (TAS) Process: Anti-apoptosis (TAS) Apoptosis (IEA) Inflammatory response (TAS) Negative regulation of cellular protein metabolic process (IC) Negative regulation of cholesterol transport (IC) Negative regulation of IL-12 biosynthetic process (IEA) Negative regulation of specific transcription from RNA polymerase II promoter (IC) Negative regulation of transcription, DNA-dependent (IEA) Positive regulation of foam cell differentiation (IC) Positive regulation of lipid metabolic process (IC) Positive regulation of transcription (NAS) |
| IL1R1 | 1.29 | 11.07 (2e-28) | MAPK signaling pathway Cytokine-cytokine receptor interaction Apoptosis Hematopoietic cell lineage |
Function: Interleukin-1, Type I, activating receptor activity (TAS) Platelet-derived growth factor receptor binding (IPI) Protein binding (IPI) Transmembrane receptor activity (TAS) Process: Cell surface receptor linked signal transduction (TAS) |
| FCGR2B | 1.29 | 7.36 (2e-13) | B cell receptor signaling pathway Systemic lupus erythematosus |
Function: Protein binding (IPI) Process: Immune response (TAS) Signal transduction (TAS) |
| INPP5D | 1.29 | 12.69 (7e-37) | Phosphatidylinositol signaling system B cell receptor signaling pathway Fc epsilon RI signaling pathway Insulin signaling pathway |
Function: Inositol-polyphosphate 5-phosphatase activity (TAS) Protein binding (IPI) Process: Phosphate metabolic process (TAS) Signal transduction (TAS) |
| ST3GAL4 | 1.29 | 5.07 (4e-7) | Glycosphingolipid biosynthesis - lacto and neolacto series |
Function: Beta-galactoside alpha-2,3-sialyltransferase activity (TAS) |
| BAAT | 1.29 | 0.52 (0.60) | Bile acid biosynthesis Taurine and hypotaurine metabolism Biosynthesis of unsaturated fatty acids |
Process: Bile acid metabolic process (TAS) Digestion (TAS) Glycine metabolic process (TAS) |
aEvidence codes defined by GO: ND (No biological Data available), EXP (Inferred from Experiment), IC (Inferred by Curator), IDA (Inferred from Direct Assay), IEA (Inferred from Electronic Annotation), IEP (Inferred from Expression Pattern), IPI (Inferred from Physical Interaction), NAS (Non-traceable Author Statement), and TAS (Traceable Author Statement).