TABLE 2.
Species | Incubation Time | Cofactor | Area Ratio | % of Loss of Substrate | % Remaining | Half-Life | Clearance |
---|---|---|---|---|---|---|---|
min | min | ml/min/kg | |||||
Rat | 0 | + | 143 | 0.0 | 100 | ||
15 | + | 12.7 | 91.2 | 8.8 | |||
30 | + | 12.2 | 91.5 | 8.5 | 4.62 | 270 | |
60 | + | 11.5 | 92.0 | 8.0 | |||
0 | − | 148 | 0.0 | 100 | |||
60 | − | 148 | 0.0 | 100 | |||
Monkey | 0 | + | 140 | 0.0 | 100 | ||
15 | + | 3.17 | 97.7 | 2.3 | |||
30 | + | 2.11 | 98.5 | 1.5 | 2.8 | 184 | |
60 | + | 1.81 | 98.7 | 1.3 | |||
0 | − | 146 | 0.0 | 100 | |||
60 | − | 144 | 1.4 | 98.6 | |||
Human | 0 | + | 133 | 0.0 | 100 | ||
15 | + | 51.4 | 61.3 | 38.7 | |||
30 | + | 15.4 | 88.4 | 11.6 | 10.6 | 58.8 | |
60 | + | 7.35 | 94.5 | 5.5 | |||
0 | − | 138 | 0.0 | 100 | |||
60 | − | 142 | No loss | 103 |