TABLE 2.

Metabolic stability of CM156 in rat, monkey, and human liver microsomes

Values are the mean of triplicate determinations, except for the zero cofactor values that are the mean of duplicate determinations. CM156 was tested at a concentration of 5 μM. Protein concentration was set at 1.0 mg protein/ml.

Species	Incubation Time	Cofactor	Area Ratio	% of Loss of Substrate	% Remaining	Half-Life	Clearance
	min					min	ml/min/kg
Rat	0	+	143	0.0	100
	15	+	12.7	91.2	8.8
	30	+	12.2	91.5	8.5	4.62	270
	60	+	11.5	92.0	8.0
	0	−	148	0.0	100
	60	−	148	0.0	100
Monkey	0	+	140	0.0	100
	15	+	3.17	97.7	2.3
	30	+	2.11	98.5	1.5	2.8	184
	60	+	1.81	98.7	1.3
	0	−	146	0.0	100
	60	−	144	1.4	98.6
Human	0	+	133	0.0	100
	15	+	51.4	61.3	38.7
	30	+	15.4	88.4	11.6	10.6	58.8
	60	+	7.35	94.5	5.5
	0	−	138	0.0	100
	60	−	142	No loss	103