TABLE 2.
TCE lever selection and operant response rates: TCE vapor alone and in combination with naltrexone, flumazenil or mecamylamine (n = 8)
Data represent the first minute of each 5-min test session.
| TCE Concentration | Percentage TCE-Lever Responding (±S.E.M.) |
Response Rate in Responses/s (±S.E.M.) |
||||||
|---|---|---|---|---|---|---|---|---|
| TCE Alone | TCE + 10 mg/kg Naltrexone | TCE + 1 mg/kg Flumazenil | TCE + 10 mg/kg Flumazenil | TCE Alone | TCE + 10 mg/kg Naltrexone | TCE + 1 mg/kg Flumazenil | TCE + 10 mg/kg Flumazenil | |
| Air only | 1 (0.2) | 1 (0.4) | 4.7 (2.9) | 1 (0.2) | 1.5 (0.2) | 1.2 (0.1) | 1.1 (0.1) | |
| Air + antagonist | — | 6.9 (5.4) | 2 (0.8) | 1 (0.4) | — | 1.4 (0.2) | 1.4 (0.1) | 1.5 (0.2) |
| 12000 ppm TCE control | 100 (0) | 99 (0.1) | 99 (0.2) | 99 (0.9) | 100 (0) | 1.6 (0.2) | 0.9 (0.2) | 1.4 (0.1) |
| 1000 ppm TCE | 14 (11.3) | 13 (12.4) | 3.5 (2.2) | 2 (1.9) | 1.8 (0.2) | 1.3 (0.2) | 1.4 (0.2) | 1.3 (0.4) |
| 2000 ppm TCE | 37 (15.5) | 1 (0.6) | 51 (18.7) | 19 (14.3)) | 1.6 (0.2) | 1.4 (0.1) | 1.4 (0.1) | 1.5 (0.3) |
| 4000 ppm TCE | 71 (15.6) | 73 (15.6) | 80 (13.3) | 51 (22.2) | 1.8 (0.2) | 1.2 (0.2) | 1.3 (0.2) | 1.3 (0.3) |
| 8000 ppm TCE | 85 (10.0) | 86 (11.4) | 99 (1.1) | 94 (4.3) | 1.6 (0.3) | 1.2 (0.1) | 1.5 (0.2) | 1.4 (0.3) |
| 12000 ppm TCE | 99 (0.2) | 99 (0.1) | 99 (0.4) | 98 (1.1) | 1.5 (0.2) | 1.3 (0.1) | 1.4 (0.1) | 1.1 (0.3) |