TABLE 3.
TCE lever selection and operant response rates: TCE vapor alone and in combination with mecamylamine or nicotine (n = 8)
Data represent the first minute of each 5-min test session.
| TCE Concentration | Percentage TCE-Lever Responding (±S.E.M.) |
Response Rate in Responses/s (±S.E.M.) |
||||||
|---|---|---|---|---|---|---|---|---|
| TCE Alone | TCE + 1 mg/kg Mecamylamine | TCE + 5.6 mg/kg Mecamylamine | TCE + 1 mg/kg Nicotine | TCE Alone | TCE + 1 mg/kg Mecamylamine | TCE + 5.6 mg/kg Mecamylamine | TCE + 1 mg/kg Nicotine | |
| Air | 1 (0.2) | 3 (1.8) | 3 (1.8) | 2 (1.1) | 1.5 (0.2) | 1.3 (0.1) | 1.3 (0.1) | 1.4 (0.2) |
| Air + combination drug | — | 2 (0.7) | 2 (0.7) | 6 (5.5) | — | 1.3 (0.1) | 1.3 (0.1) | 1.1 (0.3) |
| 12,000 ppm TCE control | 100 (0) | 99 (0.9) | 99 (0.9) | 94 (5.5) | 1.6 (0.2) | 1.3 (0.2) | 1.3 (0.2) | 1.0 (0.1) |
| 1000 ppm TCE | 14 (11.3) | 1 (0.4) | 1 (0.4) | 5 (4.1) | 1.8 (0.2) | 1.5 (0.1) | 1.3 (0.2) | 1.4 (0.2) |
| 2000 ppm TCE | 37 (15.5) | 28 (17.1) | 0 (0) | 15 (14.2) | 1.6 (0.2) | 1.5 (0.2) | 1.3 (0.1) | 1.8 (0.1) |
| 4000 ppm TCE | 71 (15.6) | 70 (17.5) | 57 (18.1) | 47 (14.9) | 1.8 (0.2) | 1.2 (0.2) | 1.0 (0.1) | 1.6 (0.1) |
| 8000 ppm TCE | 85 (10.0) | 99 (0.7) | 97 (1.9) | 97 (3.3) | 1.6 (0.3) | 1.3 (0.2) | 1.0 (0.1) | 1.5 (0.1) |
| 12,000 ppm TCE | 99 (0.2) | 99 (1.1) | 99 (0.8) | 98 (1.5) | 1.5 (0.2) | 1.2 (0.1) | 0.9 (0.1) | 1.1 (0.1) |