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. 2010 May;77(5):874–883. doi: 10.1124/mol.109.060301

Fig. 7.

Fig. 7.

Morphine treatment does not alter the magnitude or time course of LTP in hippocampal CA1 neurons but decreases the magnitude of LTD in hippocampal CA1 neurons, an effect prevented by blocking Ca2+-permeable AMPARs. A, traces above show fEPSPs recorded before and 60 min after HFS in slices from saline- (left) and morphine (right)-treated animals. The graph depicts the lack of effect of morphine on the induction and maintenance phases of LTP in hippocampal synapse. B, repeated morphine exposure decreased the magnitude of LTD and this effect is reversed by Phtx and Joro spider toxin. Graph comparing the LTD induced by LFS (1 Hz for 15 min) of hippocampal Schaffer collateral-CA1 synapses in brain slices from saline- and morphine-treated mice (fEPSP slopes 50 min after LFS: saline, 80.4 ± 3.4% of baseline; morphine, 89.4 ± 3.8% of baseline; p < 0.05, unpaired t test). Phtx and JST reverse morphine-induced decrease in the magnitude of LTD, respectively (fEPSP slopes 50 min after LFS: morphine, 89.4 ± 3.7% of baseline versus Phtx-morphine, 78.8 ± 1.5% of baseline, unpaired t test, p < 0.05; morphine, 89.4 ± 3.7% of baseline versus JST-morphine of baseline, 80.1 ± 3.0%, unpaired t test, p < 0.05).