TABLE 1.
Gene expression of redox cycling enzymes
| Gene Name | Symbol | Avg Int | WT:IKKβ(−/−) |
|---|---|---|---|
| GSH biosynthesis | |||
| Glutamate-cysteine ligase, modifier | Gclm | 1726 | 2.53 |
| Glutamate-cysteine ligase, catalytic | Gclc | 481 | 1.52 |
| Glutathione synthetase | Gss | 287 | 1.47 |
| GSH redox cycling enzymes | |||
| Glutathione reductase 1 | Gsr | 793 | 1.41 |
| Glutathione peroxidase 1 | Gpx1 | 3462 | −1.03 |
| Glutathione peroxidase 2 | Gpx2 | 39 | 1.10 |
| Glutathione peroxidase 3 | Gpx3 | 61 | 1.06 |
| Glutathione peroxidase 4 | Gpx4 | 7635 | 1.03 |
| Glutathione peroxidase 5 | Gpx5 | 24 | 1.12 |
| Glutathione peroxidase 6 | Gpx6 | 28 | 1.19 |
| Glutathione peroxidase 7 | Gpx7 | 39 | −1.13 |
| Cytochrome p450, 2e1 | Cyp2ef | 23 | 1.12 |
WT, wild type.