TABLE 2.
Gene profiling 6 to 12 h of AHR activation in thymocyte progenitors results in 108 significantly modulated gene probes
Results determined by Bonferroni-Holm correction and three-way ANOVA reporting a significant main effect with treatment, and/or significant interaction of treatment and time. The mean fold induction across all four sorted populations from TCDD-exposed mice is shown at 6 and 12 h.
| Unigene (Avadis) | Gene Symbol | Gene Title | Mean Fold Change |
|
|---|---|---|---|---|
| 6-h TCDD | 12-h TCDD | |||
| Mm0.372315 | 1700097N02Rik | RIKEN cDNA 1700097N02 gene | 1.2 | 1.1 |
| Mm0.273197 | 2010002N04Rik | RIKEN cDNA 2010002N04 gene | −1.0 | −1.7 |
| Mm0.131555 | A630007B06Rik /// LOC674488 | Similar to oocyte-testis gene 1 | −1.0 | −1.5 |
| Mm0.19941 | Acpp | Acid phosphatase, prostate | 1.2 | 1.4 |
| Mm0.291826 | Adipor2 | Adiponectin receptor 2 | 1.1 | 1.4 |
| Mm0.290446 | Ahrr | Aryl-hydrocarbon receptor repressor | 1.1 | 4.3 |
| Mm0.23125 | AI425999 | Expressed sequence AI425999 | 1.7 | 1.7 |
| Mm0.42040 | Ak3l1 /// LOC100047616 | Adenylate kinase 3 α-like 1 | −1.0 | −1.8 |
| Mm0.36006 | Ak7 | Adenylate kinase 7 | 1.5 | 1.1 |
| Mm0.398221 | Aldh3a2 | Aldehyde dehydrogenase family 3, subfamily A2 | −1.0 | −1.5 |
| Mm0.291372 | Arhgap8 | Rho GTPase-activating protein 8 | −1.2 | −3.3 |
| Mm0.380514 | AW061096 | Expressed sequence AW061096 | −1.0 | −1.7 |
| Mm0.306720 | C4bp | Complement component 4 binding protein | 1.2 | 1.5 |
| Mm0.10702 | Cacybp | Calcyclin binding protein | −1.1 | −1.1 |
| Mm0.25457 | Ccno | Cyclin O | 1.5 | 2.4 |
| Mm0.440604 | Ccr9 | Chemokine (C-C motif) receptor 9 | 1.4 | 1.1 |
| Mm0.29204 | Cd96 | CD96 antigen | 1.2 | −1.7 |
| Mm0.1135 | Cpa3 | Carboxypeptidase A3, mast cell | −1.1 | −1.5 |
| Mm0.930 | Ctsl | Cathepsin L | −1.2 | −2.4 |
| Mm0.14089 | Cyp1a1 | Cytochrome P450, family 1, subfamily a, polypeptide 1 | 1.4 | 5.2 |
| Mm0.214016 | Cyp1b1 | Cytochrome P450, family 1, subfamily b, polypeptide 1 | 2.6 | 14.1 |
| Mm0.60526 | Dmn | Desmuslin | 1.1 | 2.4 |
| Mm0.461605 | E430022K19Rik | RIKEN cDNA E430022K19 gene | 3.0 | 1.3 |
| Mm0.379893 | EG545216 /// Glcci1 /// LOC100046012 | Glucocorticoid induced transcript 1 | 1.5 | 1.4 |
| Mm0.296317 | EG624866 | Predicted gene, EG624866 | 1.1 | 1.8 |
| Mm0.38929 | Esm1 /// LOC632677 | Endothelial cell-specific molecule 1 | −1.3 | −1.4 |
| Mm0.261859 | Exoc3 | Exocyst complex component 3 | −1.5 | −1.9 |
| Mm0.28095 | Flnb | Filamin, β | −1.1 | −3.6 |
| Mm0.11982 | Gas2l3 | Growth arrest-specific 2 like 3 | 1.6 | 1.0 |
| Mm0.210787 | Glcci1 | Glucocorticoid induced transcript 1 | 1.1 | 1.5 |
| Mm0.245741 | Heg1 | HEG homolog 1 (zebrafish) | 3.2 | 1.6 |
| Mm0.57250 | Hic1 | Hypermethylated in cancer 1 | 1.0 | 1.6 |
| Mm0.239865 | Hspa4 | Heat shock protein 4 | 1.0 | 1.2 |
| Mm0.209419 | Hspa9 | Heat shock protein 9 | −1.1 | −1.0 |
| Mm0.106343 | Ikzf2 | IKAROS family zinc finger 2 | 1.4 | 1.1 |
| Mm0.731 | Il12rb1 | Interleukin 12 receptor, β1 | 1.0 | 1.6 |
| Mm0.389 | Il7r | Interleukin 7 receptor | −1.2 | −1.1 |
| Mm0.58 | Itgb7 | Integrin β7 | −2.2 | −3.1 |
| Mm0.228812 | Jakmip1 | Janus kinase and microtubule interacting protein 1 | 1.4 | 1.1 |
| Mm0.26938 | Klf2 | Kruppel-like factor 2 (lung) | −1.9 | −3.9 |
| Mm0.248615 | Lgals3 | Lectin, galactose binding, soluble 3 | −1.0 | −31.9 |
| Mm0.33240 | Mpzl2 | Myelin protein zero-like 2 | 1.4 | 1.1 |
| Mm0.28500 | Mtap | Methylthioadenosine phosphorylase | 1.0 | 1.2 |
| Mm0.275281 | Narg1 | N-methyl-d-aspartate receptor-regulated gene 1 | −1.2 | −1.1 |
| Mm0.170515 | Nfkbia | Nuclear factor of κ light chain gene enhancer in B cells inhibitor, α | 1.2 | 1.0 |
| Mm0.220367 | Nol5 | Nucleolar protein 5 | 1.2 | 1.2 |
| Mm0.402190 | Nolc1 | Nucleolar and coiled-body phosphoprotein 1 | 1.0 | 1.3 |
| Mm0.2380 | Npas2 | Neuronal PAS domain protein 2 | 2.3 | 2.6 |
| Mm0.252 | Nqo1 | NAD(P)H dehydrogenase, quinone 1 | 1.2 | 2.1 |
| Mm0.423531 | Nrp1 | Neuropilin 1 | −1.1 | −1.2 |
| Mm0.3304 | Nsg2 | Neuron specific gene family member 2 | −1.1 | −1.5 |
| Mm0.390681 | P2ry5 | Purinergic receptor P2Y, G-protein coupled, 5 | 1.4 | 1.9 |
| Mm0.259103 | Phc2 | Polyhomeotic-like 2 (Drosophila melanogaster) | −1.5 | −2.4 |
| Mm0.253819 | Pik3r3 | Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) | −1.1 | −2.7 |
| Mm0.192699 | Plcg2 | Phospholipase C, γ2 | −1.2 | −2.5 |
| Mm0.897 | Pou2af1 | POU domain, class 2, associating factor 1 | −1.1 | −1.8 |
| Mm0.70065 | Ppm1 h | Protein phosphatase 1H (PP2C domain containing) | 1.1 | 1.2 |
| Mm0.2415 | Pprc1 | Peroxisome proliferative activated receptor, γ, coactivator-related 1 | −1.2 | −1.3 |
| Mm0.379451 | Pqlc3 | PQ loop repeat containing | 1.1 | 2.0 |
| Mm0.27705 | Prim2 | DNA primase, p58 subunit | 1.3 | 1.2 |
| Mm0.16766 | Prkacb | Protein kinase, cAMP dependent, catalytic, β | 1.2 | 1.2 |
| Mm0.381172 | Prkg1 | Protein kinase, cGMP-dependent, type I | 1.2 | 1.9 |
| Mm0.103522 | Pwp2 | PWP2 periodic tryptophan protein homolog (yeast) | −1.1 | −1.4 |
| Mm0.196846 | Rad23b | RAD23b homolog (Saccaromyces cerevisiae) | 1.3 | 1.1 |
| Mm0.42150 | Rasgrp1 | RAS guanyl releasing protein 1 | 1.0 | 1.2 |
| Mm0.465324 | Rasgrp4 | RAS guanyl releasing protein 4 | −1.3 | −3.4 |
| Mm0.280068 | Rcbtb2 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 | 1.3 | 1.6 |
| Mm0.2416 | Scin | Scinderin | 1.2 | 4.3 |
| Mm0.335112 | Scn4b | Sodium channel, type IV, β | 1.2 | 3.2 |
| Mm0.245527 | Slc35b4 | Solute carrier family 35, member B4 | −1.2 | −1.5 |
| Mm0.8575 | Sox13 | SRY-box containing gene 13 | −1.9 | −1.2 |
| Mm0.260838 | St8sia1 | ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 1 | 1.4 | 1.8 |
| Mm0.198414 | Stk39 | Serine/threonine kinase 39, STE20/SPS1 homolog (yeast) | 1.3 | 4.3 |
| Mm0.197552 | Tgfbr1 | Transforming growth factor, β receptor I | 1.4 | 1.1 |
| Mm0.246767 | Thada | Thyroid adenoma associated | −1.2 | −1.6 |
| Mm0.246398 | Tiparp | TCDD-inducible poly(ADP-ribose) polymerase | 2.2 | 3.6 |
| Mm0.29431 | Tmem97 | Transmembrane protein 97 | −1.9 | −1.1 |
| Mm0.436756 | Tmprss4 | Transmembrane protease, serine 4 | −1.2 | −3.3 |
| Mm0.323595 | Tob2 | Transducer of ERBB2, 2 | 0.1 | −0.25 |
| Mm0.153272 | Tsc22d1 | TSC22 domain family, member 1 | −1.3 | −1.8 |
| Mm0.130793 | Upk1b | Uroplakin 1B | 1.4 | 2.7 |
| Mm0.268000 | Vim | Vimentin | −1.6 | −1.9 |
| Mm0.281079 | Wdr12 | WD repeat domain 12 | −1.1 | −1.1 |
| Mm0.210188 | Zcchc2 | Zinc finger, CCHC domain containing 2 | 1.3 | 1.1 |
| Mm0.446560 | Transcribed locus | 1.2 | 1.2 | |
| Mm0.441872 | Transcribed locus | 2.1 | 1.1 | |