TABLE 4.
IPA analysis of genes associated with biological functions significantly modulated by AHR activation
| Top IPA Bio Functions | P Value Range | No. of Genes |
|---|---|---|
| Diseases and disorders | ||
| Cancer | 1.26 × 10−5–3.49 × 10−2 | 35 |
| Hematological disease | 6.08 × 10−5–3.49 × 10−2 | 17 |
| Inflammatory response | 2.28 × 10−4–2.49 × 10−2 | 14 |
| Immunological disease | 3.25 × 10−4–3.49 × 10−2 | 16 |
| Gastrointestinal disease | 1.35 × 10−3–3.49 × 10−2 | 6 |
| Molecular and cellular functions | ||
| Cellular growth and proliferation | 3.01 × 10−6–3.45 × 10−2 | 29 |
| Lipid metabolism | 1.53 × 10−5–3.11 × 10−2 | 6 |
| Small molecule biochemistry | 1.53 × 10−5–3.11 × 10−2 | 15 |
| Drug metabolism | 4.59 × 10−5–1.57 × 10−2 | 3 |
| Cellular development | 9.03 × 10−5–3.45 × 10−2 | 21 |
| Physiological system development and function | ||
| Hematological system development and function | 1.77 × 10−6–3.49 × 10−2 | 21 |
| Tissue morphology | 1.77 × 10−6–2.73 × 10−2 | 16 |
| Tumor morphology | 1.26 × 10−5–2.73 × 10−2 | 10 |
| Endocrine system development and function | 1.53 × 10−5–3.11 × 10−2 | 3 |
| Respiratory system development and function | 1.52 × 10−4–3.94 × 10−3 | 2 |