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. 2010 May;77(5):715–723. doi: 10.1124/mol.109.061754

Fig. 3.

Fig. 3.

PXR activation in hAPP mice restores P-glycoprotein expression and transport of NBD-CSA. A, P-glycoprotein (P-gp) Western blot of brain capillary membranes isolated from vehicle-treated wild-type and hAPP mice and hAPP mice dosed with 25 mg/kg PCN once a day for 7 days. β-Actin was used as protein loading control (pooled tissue from 20 mice per group). B, accumulation of NBD-CSA in brain capillaries from vehicle-treated wild-type and hAPP mice and PCN-treated hAPP mice. Capillaries were incubated with 2 μM NBD-CSA for 1 h alone or with PSC833. C, data after capillary image analysis. Data are mean ± S.E.M. for 10 capillaries from one preparation (pooled tissue from 20 mice per group). Shown are arbitrary fluorescence units (scale 0–255). ***, significantly lower than control, P < 0.001.