Fig. 4.

PXR activation in hAPP mice restores P-glycoprotein-mediated hAβ42 transport. A, representative images of brain capillaries isolated from wild-type, hAPP, and PCN-treated hAPP mice. Capillaries were incubated with 5 μM fluorescein-hAβ42 for 1 h. B, data after capillary digital image analysis. Data are mean ± S.E.M. for 10 capillaries from one preparation (pooled tissue from 20 mice per group). Shown are arbitrary fluorescence units (scale 0–255). ***, significantly lower than control, P < 0.001.