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Schematic overview of the photocleavage reaction for a sulfhydryl-containing analyte captured by VICATSH. The biotinylated linker molecule remains attached to the mesh surface while the mass tagged analyte is released. The initial photocleavage product contains a carbamic acid that undergoes spontaneous decarboxylation prior to ionization to give the final photocleavage product (shown in protonated form). Capture and release results in a mass shift of 129 Da of the analyte.
