Fig. 1.

Representative ¹H spectra from a 10×10×10 mm³ voxel in the tibialis anterior (TA) muscle (see voxel location in inset) of (A) an 8 year-old girl with premature adrenarche and (B) a weight- and age-matched normal control. Detected are resonances for intramyocellular lipid (IMCL), extramyocellular lipid (EMCL) and total muscle creatine (tCr). Sample frequency-domain non-linear least-squares Gauss-Lorentzian lineshape model-fitting of the TA muscle spectra for deriving IMCL, EMCL and tCr peak areas are also shown: (a) measured spectra; (b) calculated ‘best-fit’ spectra and (dashed lines) individual components of the ‘best-fit’ spectra; and (c) residual of the difference between the measured and calculated ‘best-fit’ spectra.