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. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Science. 2009 Jun 26;324(5935):1670–1673. doi: 10.1126/science.1171837

Fig. 2.

Fig. 2

CSC models. (A) The intrinsic model suggests that specific subpopulations within a tumor (pink cells) possess the functional properties of CSCs. (B) The extrinsic model proposes that all tumor cells are functionally equivalent and display heterogeneous behaviors as a function of extrinsic (microenviron-mental) cues.