Table 3.
Age-adjusted standardized betas (SE) and p-values of peak height-MTR, WMH volume, brain atrophy and brain infarcts in models predicting time to walk (sec) for men and women of the AGES-RS cohort. As expected, lower peak-height MTR and higher WMH load are associated with longer times to walk.
| Men (n=327) | |||||
|---|---|---|---|---|---|
| Standardized betas (SE) and p-values | |||||
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
| Peak height-MTR | − 0.20 (0.009) p=0.001 |
− 0.19 (0.009) p=0.001 |
− 0.12 (0.011) p=0.10 |
− 0.19 (0.009) p=0.001 |
− 0.10 (0.011) p=0.20 |
| WMH volume 1 | 0.13 (0.020) p=0.02 |
- | 0.12 (0.020) p=0.03 |
||
| Brain atrophy | 0.14 (2.416) p=0.05 |
0.14 (2.401) p=0.05 |
|||
| Brain infarcts | - | - | 0.06 (0.117) p=0.27 |
0.04 (0.117) p=0.50 |
|
| Women (n=468) | |||||
| Standardized betas (SE) and p-values | |||||
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
| Peak height-MTR | − 0.23 (0.010) p<0.001 |
− 0.23 (0.010) p<0.001 |
− 0.15 (0.012) p=0.01 |
− 0.22 (0.010) p<0.001 |
− 0.14 (0.012) p=0.01 |
| WMH volume 1 | 0.12 (0.019) p=0.004 |
- | 0.11 (0.019) p=0.01 |
||
| Brain atrophy | 0.14 (2.52) p=0.01 |
0.14 (2.50) p=0.01 |
|||
| Brain infarcts - | - | - | 0.09 (0.247) p=0.04 |
0.06 (0.249) p=0.20 |
|
1
Includes subcortical WMH. Adjustment for periventricular WMH (alone or in combination with subcortical WMH) yields similar results.