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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: Prog Lipid Res. 2010 Jan 4;49(3):218–234. doi: 10.1016/j.plipres.2009.12.003

Fig. 8.

Fig. 8

ACBD3, a central node in steroidogenesis. A. Gene networks were constructed through the IntNetDB server (http://hanlab.genetics.ac.cn/IntNetDB.htm) and visualized by BioLayout (http://www.biolayout.org) using human ACBD3 (Gene ID: 64746), TSPO (Gene ID: 706), and PRKAR1A (Gene ID: 5573) genes as probes, respectively. B. A 3D graph of the ACBD3 gene network, with collapsed TSPO- and PRKAR1A- groups. Steroid and cholesterol synthesis-related genes (in green) in the ACBD3 gene network: STAR, steroidogenic acute regulatory protein; SCP2, sterol carrier protein 2; FDFT1, farnesyl-diphosphate farnesyltransferase 1 (squalene synthase); NSDHL, NAD(P) dependent steroid dehydrogenase-like; LSS, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); IDI1, isopentenyl-diphosphate delta isomerase 1; STARD3, StAR-related lipid transfer (START) domain containing 3; HSD17B7, hydroxysteroid (17-beta) dehydrogenase 7; HSD17B12, hydroxysteroid (17-beta) dehydrogenase 12; HSD17B8, hydroxysteroid (17-beta) dehydrogenase 8; CYB5R4, cytochrome b5 reductase 4 (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase). Hormone nuclear receptor (in dark blue): NR0B1, nuclear receptor subfamily 0, group B, member 1. Acyl coenzyme-related: DBI, diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein); BACH (ACOT7), acyl-CoA thioesterase 7 (brain acyl-CoA hydrolase). Golgi proteins: BLZF1, basic leucine zipper nuclear factor 1 (JEM-1). Lipid degradation: AZGP1, alpha-2-glycoprotein 1, zinc-binding. Emp24 family (in yellow): TMED1, transmembrane emp24 protein transport domain containing 1; TMED9, transmembrane emp24 protein transport domain containing 9; TMED5, transmembrane emp24 protein transport domain containing 5; TMED3, transmembrane emp24 protein transport domain containing 3; RNP24, transmembrane emp24 domain trafficking protein 2 (transmembrane emp24 domain trafficking protein 2); TMED7, transmembrane emp24 protein transport domain containing 7; FYCO1, FYVE and coiled-coil domain containing 1.