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. Author manuscript; available in PMC: 2011 May 1.

Published in final edited form as: J Matern Fetal Neonatal Med. 2010 May;23(5):409–416. doi: 10.1080/14767050903168424

Relative amounts of bound and free bupropion in maternal and fetal media in absence (3A) and presence (3B) of human serum albumin (HSA) following its perfusion for 4 hours.

(3A) In media of the maternal circuit devoid of added HSA: 17 ± 17% of bupropion was bound and the remainder was free. In the fetal circuit, bupropion was in its free form.

(3B) In presence of 30 mg/mL HSA (physiologic concentration) added to media of both maternal and fetal circuits: elution of bupropion in the void volume of the column increased to 24 ± 12% in the maternal circuit. In the fetal circuit, bupropion was eluted 11 ± 4% as bound fraction.

Relative amounts of bound and free bupropion in maternal and fetal media in absence (3A) and presence (3B) of human serum albumin (HSA) following its perfusion for 4 hours.

(3A) In media of the maternal circuit devoid of added HSA: 17 ± 17% of bupropion was bound and the remainder was free. In the fetal circuit, bupropion was in its free form.

(3B) In presence of 30 mg/mL HSA (physiologic concentration) added to media of both maternal and fetal circuits: elution of bupropion in the void volume of the column increased to 24 ± 12% in the maternal circuit. In the fetal circuit, bupropion was eluted 11 ± 4% as bound fraction.