Figure 1.

Representative ³¹P NMR spectra from sham, untreated (PBS), control MSC-treated, and Akt-MSC-treated heart at baseline. For each spectrum, peaks from left to right represent Pi, PCr, and γ-, α and β-phosphates of ATP. (A): Note that at 72 hours the PCr peak is decreased in the PBS and MSC groups compared with both the sham and the Akt-MSC-treated hearts. (B): After 2 weeks, the PCr peak recovered both in the PBS and control MSC groups to baseline levels. Abbreviations: Akt-MSC, MSCs overexpressing Akt1; MSC, mesenchymal stem cells; PBS, phosphate-buffered saline; PCr, phosphocreatine; Pi, inorganic phosphate.