. Author manuscript; available in PMC: 2010 May 19.

Published in final edited form as: Stem Cells. 2009 Apr;27(4):971–979. doi: 10.1002/stem.12

Table 2.

Left ventricular function in sham, untreated (PBS), control MSC treated (MSC), and Akt-MSC treated animals at 72 hours and 2 weeks after myocardial infarction

	Sham (n=9)	PBS (n=7)	MSC (n=7)	Akt-MSC (n=9)
72 hours
DevP (mmHg)	98 ± 2	60 ± 5^*	68 ± 3^*	86 ± 3^*^#^†
RPP (mmHg/min)	29,131 ± 733	18,487 ± 1,588^*	21,661 ± 1,159^*	25,656 ± 948^*^#^†
+dP/dt (mmHg/min)	3,027 ± 63	1,893 ± 93^*	1,988 ± 93^*	2,760 ± 114^#^†
−dP/dt (mmHg/min)	2,008 ± 72	1,254 ± 65^*	1,280 ± 89^*	1,919 ± 71^#^†
2 weeks
DevP (mmHg)	102 ± 4	55 ± 6^*	61 ± 2^*	84 ± 5^*^#^†
RPP (mmHg/min)	31,148 ± 2.080	18,675 ± 2,927^*	18,790 ± 1,280^*	25,089 ± 2,131^*^#^†
+dP/dt (mmHg/min)	2,894 ± 69	1,866 ± 172^*	1,824 ± 66^*	2,406 ± 135^*^#^†
−dP/dt (mmHg/min)	1,868 ± 233	1,195 ± 167^*	1,094 ± 103^*	1,712 ± 170^#^†

Values expressed as average ± SE

p<0.05 vs sham

p<0.05 vs PBS

^†

p<0.05 vs control MSC.

Abbreviations: Akt-MSC, MSCs overexpressing Akt1; DevP, LV developed pressure; þdP/dt, maximum values within a beat of the first derivative of left ventricular pressure; −dP/dt, minimum values within a beat of the first derivative of left ventricular pressure; MSC, mesenchymal stem cells; PBS, phosphate-buffered saline; RPP, rate-pressure product.