Matching two ribonuclease proteins (PDB IDs 1MO7 and 215S). Both have similar functional sites, occupying the center groove. (a) Shows large-scale curvature matching for the picked site (blue and white circle in the center of each top image). In (b), degree-of-anistropy is used instead. In (c), both metrics are combined, yielding a more accurate match in the bottom image to the picked point in the top image. Finally, (d) shows, for comparison, the results from matching using Rusinkiewicz’s local curvature estimation technique [34].