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. Author manuscript; available in PMC: 2011 Jun 20.
Published in final edited form as: Virology. 2010 Apr 7;402(1):94–101. doi: 10.1016/j.virol.2010.03.001

Figure 7. Proposed models for HPV-E1 and AAV Rep78 interaction.

Figure 7

Shown are depictions of three models for E1-associated enhancement of Rep78-ITR biochemistry. The “escort” model depicts E1 promoting Rep78-multimerization. The “peripheral” model depicts the “escortd model plus a continued weak association of E1 with the Rep78-ITR complex, which is too weak to be observed by EMSA. The “integrated” model suggests substitution of E1 in place of some Rep78 molecules within the Rep78-ITR complex itself. This latter model is the least likely.