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. Author manuscript; available in PMC: 2011 May 17.
Published in final edited form as: Chembiochem. 2010 May 17;11(8):1093–1106. doi: 10.1002/cbic.200900671

Scheme 2. Proposed reaction mechanism accounting for the identified products generated from (Z,E)-FPP by Cop4, Cop6 and NS1.

Scheme 2

Numbered reaction arrows indicate different branch points in the cyclization reaction. Relative amounts of products formed by each enzyme are shown in Table 2. (6S)-β-bisabolene is also formed as a product (18%) by the mutant form of Cop 6 (N224D), thus providing strong evidence for the common 6S stereochemistry of β-bisabolyl cation intermediate generated by Cop 6.