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. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Ann Intern Med. 2010 Mar 2;152(5):276–286. doi: 10.1059/0003-4819-152-5-201003020-00005

Figure 2.

Figure 2

Univariate Sensitivity Analyses. The incremental cost-effectiveness ratio of ECG plus cardiovascular focused history and physical versus no screening (A) and ECG plus cardiovascular focused history and physical vs. cardiovascular focused history and physical alone (B) are shown as changed by varying critical parameters through possible ranges. The base case estimates (A, $76,100 per life year saved and B, $42,900 per life year saved) are shown (vertical lines). Horizontal solid boxes represent the incremental cost effectiveness ratio resulting from inputting the described variable over the expected range of the mean value (also used in probabilistic sensitivity analysis); horizontal lines represent incremental cost effectiveness ratio found using expected minimum and maximum inputs, which may be applicable to certain specific subgroups or to particular payors. The accompanying table lists, from left to right: the low value input, the low input used for probabilistic sensitivity analysis, the high value input used for probabilistic sensitivity analysis, and the high value input for each variable or combination of variables. In (B), note the incremental cost effectiveness ratio between ECG plus H&P and H&P alone is not dependent on H&P cost, but is dependent on the interpretation of H&P results prior to ECG interpretation. ECG plus H&P, 12-lead electrocardiogram plus cardiovascular-focused history and physical. CV focused H&P, cardiovascular-focused history and physical. Risk ratio, Athlete vs. DQ represents the mortality risk reduction associated with disqualification and treatment of athletes with underlying occult heart disease versus continued participation without diagnosis. ECG cost, cost of ECG above H&P cost. All screening costs, all cost parameters including primary and secondary screening tests, initial and recurring screening related treatment costs input into model concurrently. SCD, sudden cardiac death, DQ, disqualified, SN, sensitivity; SP, specificity. † ECG plus cardiovascular focused history and physical cost and life saving versus comparator. * Base case assumption.