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. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Cancer Res. 2010 May 11;70(10):3896–3904. doi: 10.1158/0008-5472.CAN-09-3995

Figure 1. Proposed dual targeting mechanism by β-lap nanotherapeutics.

Figure 1

Depicted is a simplified model that summarizes the pharmacokinetic and pharmacodynamic targeting strategy provided by β-lap micelles. A. Polymer micelles provide long circulation and reduced drug clearance that enhances accumulation in tumor tissue, wherein, micelles are internalized into cells and drug is released. B. Tumor cell killing is accomplished through the NQO1-dependent mechanism of action of β-lap, a unique pattern of cell death referred to as “programmed necrosis” or “necroptosis”.