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Re-estimation of statistical power for hypertension in the Wellcome Trust Case Control Consortium (WTCCC). Computation of power used variance components tools, implemented at <http://pngu.mgh.harvard.edu/~purcell/gpc>, considering a spectrum of reasonable assumptions (disease allele relative risk; marker and disease allele frequencies; D’ [linkage disequilibrium]), as well as the effects of the likely ~25% trait misclassification in the “control” group.
