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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: J Hypertens. 2010 Jun;28(6):1115–1123. doi: 10.1097/HJH.0b013e328337f6bc

Figure 2. Common Disease/Rare Variant (CD/RV) hypothesis. Human CHGA/Catestatin Gly364Ser (~3% minor allele frequency).

Figure 2

Profound effects on autonomic function and BP in vivo. Left: Effects of Gly/Ser heterozygosity on catecholamine secretion. Center: Effects of Gly/Ser heterozygosity on autonomic function (baroreceptor sensitivity as measured in either the time or frequency domains). Right: Effect of Gly/Ser heterozygosity on resting DBP in the population, with replication in an independent sample. CHGA Gly364Ser is rs9658667. Reproduced from F Rao et al46.