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. 2009 Apr 22;29(16):5354–5363. doi: 10.1523/JNEUROSCI.0131-09.2009

Figure 2.

Figure 2.

HF stimulation produces a time-dependent increase in slow/delta oscillations selectively in the OFC. A, HF NAC DBS produces a time-dependent enhancement of slow oscillations (0.5–4 Hz) in OFC compared with LF and SHAM DBS (top left). Analysis of LFP activity with HF DBS on demonstrates that this effect was not apparent early in the stimulation period, but was maintained during the “off” period (top right). There were no changes in delta oscillations in the other regions with any stimulation frequency (bottom). *Significantly different from LF and SHAM. B, Representative OFC voltage traces and time–frequency spectrograms before and after 90 min HF NAC DBS showing increased low frequency activity following 90 min DBS. Calibration: 5 s, 0.2 mV.