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. Author manuscript; available in PMC: 2010 May 19.
Published in final edited form as: Anat Rec (Hoboken). 2009 Jul;292(7):1045–1061. doi: 10.1002/ar.20921

Figure 4. Systemic Administration of Rosiglitazone to Neonatal Mice Attenuates the Adverse Histological Effects of Hyperoxic Exposure in Developing Murine Lungs.

Figure 4

Newborn mouse litters (postnatal day 0/1 of age) were exposed to RA or 70% oxygen for 10 days, a period corresponding to the late terminal saccular / early alveolar stages of lung development. The dams were fed a standard diet of chow impregnated with ROSI from P0 and litters exposed to RA or HE. Following HE animals were placed at RA. Moderate exposure of neonatal mice to hyperoxia during week one of life resulted in subtle changes in lung histology evident by hematoxylin and eosin stained lung tissue sections on P13 (A vs E) with lung simplification evident by P41 (BvsF). In contrast to HE alone ROSI+HE had increased alveolar structures (G&H) and ROSI treatment during RA had no apparent effect on lung structure (C&D). Scale bar=50uM.