Table 7.
Mean (SD) annualised percentage rates of atrophy in the left hippocampus in the baseline images of the subset of 15 subjects used to assess optimal methods and parameters.
| Control (n=5) | MCI (n=5) | AD (n=5) | |
|---|---|---|---|
| manual | 1.53 (2.27) | 4.73 (2.02) | 5.44 (1.90) |
| manualHBSI | 1.28 (4.19) | 4.89 (2.81) | 6.97 (1.40) |
| MAPS-HBSI | 1.49 (3.87) | 5.18 (2.80) | 6.48 (1.06) |
| manualHBSI vs manual | |||
| difference in means (95% CI) |
-0.26 (-4.36 to 3.85), p=0.87 |
0.16 (-1.89 to 2.2) p=0.84 |
1.53 (0.27 to 2.79) p=0.03 |
| SD of the difference | 3.33 | 1.65 | 1.01 |
| SD ratio (95% CI) | 1.85 (0.58 to 5.91) p=0.25 |
1.39 (0.55 to 3.51) p=0.39 |
0.76 (0.31 to 1.72) p=0.38 |
| MAPS-HBSI vs manual | |||
| difference in means (95% CI) |
-0.04 (-3.90 to 3.81) p=0.98 |
0.46 (-1.41 to 2.32) p=0.53 |
1.05 (-0.97 to 3.06) p=0.22 |
| SD of the difference | 3.10 | 1.50 | 1.62 |
| SD ratio (95% CI) | 1.71 (0.52 to 5.55) p=0.31 |
1.38 (0.59 to 3.24) p=0.35 |
0.56 (0.16 to 1.91) p=0.30 |
| MAPS-HBSI vs manualHBSI | |||
| difference in means (95% CI) | 0.21 (-0.28 to 0.70) p=0.30 |
0.30 (-0.61 to 1.20) p=0.41 |
-0.48 (-1.94 to 0.97) p=0.41 |
| SD of the difference | 0.40 | 0.73 | 1.17 |
| SD ratio (95% CI) | 0.92 (0.83 to 1.03) p=0.10 |
0.99 (0.63 to 1.57) p=0.97 |
0.76 (0.23 to 2.51) p=0.59 |