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. Author manuscript; available in PMC: 2010 Jun 1.
Published in final edited form as: J Infect Dis. 2010 Jun 1;201(11):1708–1717. doi: 10.1086/652496

Figure 5.

Figure 5

Activated transfected killer (ATAK) cells are bioluminescent in vitro and in vivo. Mice were made neutropenic and infected with a sublethal inoculum of Candida albicans. Mice were treated with irradiated ATAK cells or saline control starting 3 h after infection and repeated on days 2, 4, and 6 after infection. Mice were imaged with the in vitro imaging system (IVIS; Caliper Life Sciences) 24 h after the first treatment (A); 24 h after the last treatment, which was 1 day after neutrophil recovery (B); or 2 months after neutrophil recovery (C). The mice imaged at 2 months after neutrophil recovery had been treated with ganciclovir (5 mg/kg given intraperitoneally on days 16 and 18 after infection, which was 1 week after neutrophil recovery). One saline control mouse (left) and 2 ATAK-treated mice (middle and right) are shown in each panel and are representative of 5 mice per group. The photon intensity scale shown is as follows: red→yellow→green→blue.