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Vulnerability of wild-type and Oligo-COX-2 transgenic oligodendrocytes to KA-induced excitotoxicity. Dispersed oligodendrocytes were treated to varying concentrations of KA and examined for cell death 24 hours later. Oligodendrocytes derived from the transgenic animals were 8-fold more sensitive to KA than wild-type. Note, the x-axis is not a linear scale.
