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ABZ inhibits tumoral VEGF protein and mRNA. In mice bearing intra peritoneal OVCAR-3 tumors, acute treatment with albendazole (150 mg/kg, i.p.) led to time-dependent suppression of tumoral VEGF levels. The peak anti-VEGF effect was observed in tumors harvested 24 to 48 h post drug administration (A). RT-PCR analysis of the tumor samples revealed complete depletion of VEGFmRNA in these tumors (B).
