Table 2.

Cox-proportional regression analysis results of overall survival time of 100 breast cancer patients with bone metastasis.

					Patients with available sequential TRACP 5b activities
	Total	cohort	n = 100		Lower	2/3*	n = 54		Top	1/3*	n = 27
	HR**	CI**		p***	HR	CI		p	HR	CI		p
Age	ns****	-	-	ns	0.945	0.896	0.997	0.0384	ns	-	-	ns
Baseline TRACP 5b activity	3.524	2.066	6.010	< 0.001	-	-	-	-	-	-	-	-
ΔmaxTRACP 5b*****	-	-	-	-	ns	-	-	ns	0.213	0.082	0.555	0.0015
CEA	ns	-	-	ns	ns	-	-	ns	ns	-	-	ns
CA15.3	ns	-	-	ns	ns	-	-	ns	ns	-	-	ns
ER positivity	0.397	0.240	0.656	0.0003	0.260	0.103	0.655	0.0043	0.374	0.148	0.947	0.0379
HER-2/neu positivity	ns	-	-	ns	ns	-	-	ns	ns	-	-	ns
Visceral metastasis absent	0.492	0.301	0.802	0.0045	ns	-	-	ns	ns	-	-	ns

*. Two Group are classified by the baseline TRACP 5b activity in the top 1/3 (TRACP 5b ≥ 5.736 U/L) and bottom 2/3 (TRACP 5b < 5.736U/L)

**. HR = Hazard ratio; CI = Confidence interval

***. p = p value of each variant

****. ns= Not significant

*****. Maximal interval change of TRACP 5b as a dichotomous variable (Δmax TRACP 5b × 38.59% versus ≤ 38.59%).