Table 5.

Functions of the biologically relevant genes found in prostate cancer.

Gene Name	Gene Function	Evidence References
HPN	Plays an essential role in cell growth and maintenance of cell morphology.	[59]
S100A4	S100 calcium binding protein A4.	[52]
RBP1	Intracellular transport of retinol.	[25]
ANGPT1	Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.	[50]
COL4A6	Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans, and entactin/nidogen.	[53]
NELL2	Chicken nel-like 2 homolog with a wide and weak expression, expressed in adult and fetal brain and hemopoietic cells (nucleated peripheral blood cells) but not in B cells.	[48]
GSTM1	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.	[49]
PTGDS	It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.	[54]
TARP	Transmembrane receptor activity.	[58]
LMO3	Lim domain only 3.	[56]
DIO2	Essential for providing the brain with appropriate levels of T3 (3,5,3'-triiodothyronine) during the critical period of development.	[57]
SERBP1	May play a role in the regulation of mRNA stability.	[55]
TNFSF10	Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.	[51]