Table 2.
Clinical and biochemical characteristics of NAFLD Compared with NASH Subjects.
| NAFLD | NASH |
P-value NAFLD Vs NASH |
|
|---|---|---|---|
| Age (yrs) | 47.2 ± 11.1 | 50.4 ± 13.3 | NS |
| BMI (kg/m2) | 32.6 ± 5.7 | 35.0 ± 6.0 | p < 0.05 |
| Endotoxin (EU/mL) # | 12.3(7.3, 15.6) | 10.9(7.8, 13.9) | NS |
| Fibrosis score: 0 | 12.3(6.6, 17.2) | 8.6(5.5, 11.7) | |
| 1 | 13.3(11.1, 15.6) | 11.7(8.0, 17.2) | |
| 2 | 7.1(7.1, 7.1) | 11.7(8.2, 15.0) | |
| 3 | NA | 12.6(9.4, 14.5) | |
| 4 | NA | 8.2(5.2, 11.2) | |
| Insulin (μU/mL) # | 18.3(8.1, 22.3) | 30.4(14.6, 36.3) | p < 0.001 |
| Fibrosis score: 0 | 16.7(8.1, 21.1) | 29.1(9.8, 26.2) | |
| 1 | 37.2(8.7, 76.3) | 26.8(14.2, 33.4) | |
| 2 | NA | 27.4(16.3, 36.9) | |
| 3 | NA | 38.6(18.4, 67.2) | |
| 4 | NA | 37.0(17.6, 54.8) | |
| Glucose (mmol/L) # | 5.5(4.8, 6.1) | 6.6(4.8, 7.0) | p = 0.01 |
| Fibrosis score: 0 | 5.4(4.8, 5.9) | 6.9(4.5, 6.2) | |
| 1 | 6.6(4.8, 8.3) | 5.5(4.7, 5.8) | |
| 2 | 6.7(6.7, 6.7) | 5.7(4.5, 6.4) | |
| 3 | NA | 8.0(5.5, 9.2) | |
| 4 | NA | 8.2(5.0, 10.8) | |
| HOMA-IR # | 4.8(1.7, 5.6) | 8.6(3.3, 13.3) | p < 0.001 |
| Fibrosis score: 0 | 4.1(1.7, 5.4) | 7.4(1.9, 7.3) | |
| 1 | 12.4(1.8, 27.0) | 7.0(3.0, 8.6) | |
| 2 | NA | 6.9(3.3, 9.1) | |
| 3 | NA | 12.8(4.4, 22.5) | |
| 4 | NA | 12.7(7.0, 21.9) | |
| TNF-α (pg/mL) # | 8.3(4.2, 7.3) | 14.7(5.0, 8.9) | p < 0.05 |
| Fibrosis score: 0 | 8.6(4.2, 7.4) | 7.4(4.7, 8.0) | |
| 1 | 6.0(4.0, 8.9) | 16.6(5.1, 6.9) | |
| 2 | 6.3(6.3, 6.3) | 8.5(4.9, 10.6) | |
| 3 | NA | 43.7(4.4, 21.6) | |
| 4 | NA | 6.7(4.7, 9.0) | |
| sCD14 (ng/mL) # | 1575.0(1242.6, 1840.8) | 1805.2(1374.8, 2169.6) | p = 0.01 |
| Fibrosis score: 0 | 1533.3(1224.6, 1809.2) | 1716.0(1331.1, 2018.2) | |
| 1 | 1851.2(1319.3, 2408.3 | 1642.2(1302.1, 1857.5) | |
| 2 | 1747.1(1747.1, 1747.1) | 1829.3(1558.2, 2253.3) | |
| 3 | NA | 1870.0(1680.2, 2080.5) | |
| 4 | NA | 2000.3(1361.0, 2460.1) | |
| sTNFRII (pg/mL) # | 2097.3(1642.42453.7) | 2676.9(2075.6, 3034.2) | p < 0.001 |
| Fibrosis score: 0 | 2062.9(1621.2, 2445.0) | 2491.0(2076.8, 2377.6) | |
| 1 | 2292.8(1729.0, 3067.5) | 2330.2(1991.2, 2752.2) | |
| 2 | 2494.9(2494.9, 2494.9) | 2597.2(1833.7, 3341.7) | |
| 3 | NA | 2688.9(1962.0, 3047.1) | |
| 4 | NA | 3538.0(2558.3, 4229.2) | |
Data are presented as mean (± SD) unless log transformed (#) in which case they are presented as mean (interquartile range). NA refers to no data available as there were no subjects in this group.