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Overall structure of PfNapS. (a) Domain diagram for NAP/SET crystal structures determined so far. Architecture of PfNapS, yNAP-1, Vps75, hSET and PfNapL highlighting the 'accessory domain' in yNAP-1 (coloured yellow) which is missing in the remaining 4 structures (set to scale). (b) Structure of the PfNapS dimer. Each monomer of PfNapS contains domain I comprised of dimerization helix α2 and domain II comprised of a β sub-domain (4 anti-parallel β strands) and α-helices.
