Table 4.
Structure-based comparison with hSET mutagenesis data of residues which effect binding (completely or partially) to histones
| hSET | PfNapL | PfNapS | Vps75 | yNAP-1 | |
|---|---|---|---|---|---|
| 1 | S162 | D192 | E161 | Q150 | D278 |
| 2* | K164 | K194 | K163 | D152 | H281 |
| 3 | D165 | N195 | N164 | S153 | N282 |
| 4 | T191 | H227 | E187 | G181 | N314 |
| 5* | T194 | T230 | T190 | R184 | D317 |
| 6 | D195 (disordered) | S231 | T191 | W185 | D317 |
| 7 | D202 | Y259 | P198 | D198 | Y342 |
| 8* | E203 | E260 | D199 | S199 | S343 |
| 9* | E206 | L263 | E202 | S202 | E246 |
| 10* | K209 | K266 | R205 | S205 | K349 |
| 11 | D210 | E267 | R206 | E206 | D350 |
| 12* | D211 | R268 | E207 | E207 | K351 |
| 13 | E187 (disordered) | D223 | W183 | K177 | E320 |
*conserved in PfNapS