Table 2.

Associations of prostate cancer stage and Gleason grade with the usual reaction of the skin when first exposed to sunlight and measures of sun exposure throughout the life course (odds ratios compare localised versus advanced or low versus high grade cancers)

	Localised	Advanced	Age, sunscreen use and pigmentation* adjusted			Low Grade (<7)	High Grade (≥ 7)	Age, sunscreen use and pigmentation* adjusted
	n (%)	n (%)	OR	95% CI	p-trend	n (%)	n (%)	OR	95% CI	p-trend
	899	116				686	317
Usual reaction of skin when first exposed to sunlight
Always/easily burns	308 (35.0)	48 (42.5)	1			242 (35.9)	111 (36.0)	1
Burns rarely/never	573 (65.0)	65 (57.5)	0.71	(0.47,1.08)	0.11	432 (64.1)	197 (64.0)	0.98	(0.72,1.31)	0.87
Time spent Outside (5-69 years)
High	331 (38.0)	50 (45.1)	1			245 (36.7)	130 (42.9)	1
Medium	311 (35.7)	42 (37.8)	0.93	(0.59,1.47)		241(36.1)	107 (35.3)	0.89	(0.64,1.23)
Low	230 (26.4)	19 (17.1)	0.49	(0.27,0.89)	0.03	182 (27.3)	66 (21.8)	0.62	(0.43,0.91)	0.02
Intense Sun Exposure (0-last 2 years**)
High	237 (28.1)	27 (25.5)	1			173 (27.0)	87 (29.4)	1
Middle	419 (49.7)	52 (49.1)	0.95	(0.57,1.58)		327 (51.0)	138 (46.6)	0.81	(0.58,1.14)
Low	187 (22.2)	27 (25.5)	1.00	(0.54,1.83)	0.98	141 (22.0)	71 (24.0)	0.87	(0.54,1.32)	0.48

^*Usual reaction of skin when first exposed to sunlight, natural hair colour, skin colour at age 20

^**Prior to the prostate check clinic at ages 50-69