Table 1.

Summary of Main Epidemiologic Data

	References
In the general population, the incidence of NSAID hypersensitivity in young children is low, although it may equal that found in healthy adults	[5]
ADRs account for only 4.3% of general pediatric hospitalizations, but ASA-containing medications constitute approximately one-fifth of these and tend to cause clinically severe reactions	[6,7]
About a third of children developing acute NSAID hypersensitivity in a medical setting are 6 years old or younger	[7,8]
Atopy and allergic disease are the most significant risk factors for the development of NSAID hypersensitivity in young children (and older ones)	[14,15]
The prevalence of NSAID hypersensitivity in atopic children is 2% but lower in the young age group and increases with age	[13]
The incidence of challenge-derived ASA hypersensitivity in asthmatics depends on the diagnostic protocol used	[9-12]
In the young age group, there is no female preponderance (like that seen in adults with ASA-sensitive asthma)	[15,16]
Antipyretic doses of ibuprofen in young children do not seem to increase the risk of hospitalization due to asthma or bronchitis compared with acetaminophen	[17]
The risk of acute exacerbations in young asthmatic children during an acute illness is not increased by the use of antipyretic doses of ibuprofen	[18]

ADR = adverse drug reaction; ASA = acetylsalicylic acid; NSAID = nonsteroidal anti-inflammatory drug.