Table 2.

Summary of Clinical Presentations of NSAID Hypersensitivity in Preschool Children

	References
Nonspecific, cross-reactive, COX inhibitor related
ASA-exacerbated respiratory disease (AERD)	[9-12,32]
Angioedema/urticaria in children with chronic urticaria	[33-37]
Angioedema/urticaria in children without chronic urticaria	[15,38-40]
Mixed reactions (angioedema/urticaria and acute respiratory symptoms, bronchospasm)	[15,41]
The most common clinical manifestation of NSAID hypersensitivity at this age is facial angioedema with or without generalized urticaria	[13,15]
Drug-specific, immune-mediated reactions
Immediate single drug-mediated urticaria/angioedema	[38,42]
Delayed-type hypersensitivity reactions (eg, fixed drug eruptions and toxic epidermal necrolysis)	[38,43-46]
No publications of ASA-/NSAID-induced aseptic meningitis or hypersensitivity pneumonitis were identified

ASA = acetylsalicylic acid; COX = cyclooxygenase; NSAID = nonsteroidal anti-inflammatory drug.